Rancho Bernardo residents enjoy easy access to anywhere in San Diego County. Interstate 15 runs directly through Rancho Bernardo, with State Route 56 lying just south of the community and Highway 78 to the north. San Diego International Airport is less than 30 minutes away.

Local bus transportation is provided through the North County Transit System and the San Diego Transit System. There are bus stops throughout the community with regularly scheduled stops every day of the week.